No1(2) 2019
Back to the issue
|
DOI 10.37219/2528-8253-2019-1-26 |
Melnikov OF, Rylska ОG, Shmatko VI, Timchenko МD, Bil BN,
Faraon IV, Prylutska OD, Zayats ТА
Effect of esberitox phytopreparation on factors of local immunity of the
oral cavity
|
Melnikov Oleg F.
State Institution “Institute of otolaryngology named after Prof. O.S.
Kolomiychenko of the National Academy of Medical Sciences of Ukraine”; Kyiv,
Ukraine. Head of the Laboratory of Pathophysiology and Immunology (with a
group of pathomorphology), Doctor of Medical Sciences, Professor
E-mail: elenamelnykova@gmail.com
Rylska Oksana G.
State Institution “Institute of otolaryngology named after Prof. O.S.
Kolomiychenko of the National Academy of Medical Sciences of Ukraine”; Kyiv,
Ukraine. Senior Researcher at the Department of In-flammatory Diseases of
ENT Organs, Candidate of Medical Sciences.
Email: oxanar@ua.fm
Shmatko Vladimir
Bogomolets National Medical University, child therapeutic dentistry and
prevention of dental diseases, the Candidate of Medical Sciences, Assistant
Professor, responsible for medical advisory work at the Department, rating
evaluation of students on the Department.
E-mail: kancnmu@gmail.com
Orcid: http://orcid.org/0000-0001-5402-1905
Timchenko Мarina D.
State Institution “Institute of otolaryngology named after Prof. O.S.
Kolomiychenko of the National Academy of Medical Sciences of Ukraine”; Kyiv,
Ukraine. Senior Researcher, Laboratory of Pathophysi-ology and Immunology
(with a group of pathomorphology), candidate of biological sciences.
E-mail: svtim@i.ua
Bil Bogdan N.
Chief otolaryngologist in Kiev, head of the State Research Center for
Endoscopic Rhinolaryngology and the City Phoniatric Center, head of the
department of otolaryngology of the Kiev City Clinical Hospital No. 9,
candidate of medical sciences, associate professor of the Department of
Otolaryngology of the Shupik National Medical Academy of Postgraduate
Education.
Email: bohdanbill@gmail.com
Faraon Inna V.
State Institution “Institute of otolaryngology named after
Prof. O.S. Kolomiychenko of the National Academy of Medical Sciences of
Ukraine”; Kyiv, Ukraine, Junior Researcher, Laboratory of Pathophysiology
and Immunology (with a group of pathomorphology).
E-mail: amtc@kndio.kiev.ua
Zayac Tatiana A.
State Institution “Institute of otolaryngology named after Prof. O.S.
Kolomiychenko of the National Academy of Medical Sciences of Ukraine”; Kyiv,
Ukraine, Researcher, Laboratory of Pathophysiology and Immunology (with a
group of pathomorphology).
E-mail: amtc@kndio.kiev.ua |
|
Abstract
Introduction: Among a large number of immunomodulation agents, a
special role belongs to herbal medicines. They differ in relative
harmlessness and high efficiency, both with system and local use. Clinical
and immunological efficacy of Esberitox phytopreparation (Schaper&Brummer,
Germany) in a number of diseases of viral and microbial origin has been
shown. This report presents data on the effect of Esberitox on the factors
of local immunity of the oral cavity in patients with chronic pharyngitis,
tonsillitis and periodontitis with systemic use of Esberitox in monotherapy.
Methods: The oropharyngeal secret of 10 patients with chronic
tonsillitis (CT), 11 patients with chronic pharyngitis (CP), (all patients
after tonsillectomy), 10 patients with chronic periodontitis was
investigated. Patients were given monotherapy with «Esberitox» for 10 days
(CP), according to the manufacturer's instructions for use of the drug. In
addition, 9 practically healthy persons (K) of the same age (18-50 years)
were examined. The ELISA method was used to determine the class A
immunoglobulins (secretory and monomeric), IgG, α-interferon,
interleukin-1β, levels of immune complexes. Statistics: Mann-Whitney U-test.
Results: Studies have shown that in patients with chronic
inflammatory diseases of the oral cavity there is a decrease in the
protective factors of local immunity – the level of secretory IgA, antiviral
factor – α-interferon and an increase in the level of pro-inflammatory
cytokine – interleukin-1β, monomeric form of IgA and the number of immune
complexes. The use of «Esberitox» as a monotherapy was accompanied by an
increase in the concentration of class A secretory immunoglobulin, the
«normalization» of the α-interferon content (increase in concentration) and
interleukin-1β (decrease in content).
Conclusion: The resulting positive effects from the use of esberitox
allow us to recommend the drug as part of the complex therapy of chronic
diseases of the oropharynx, and in the form of monotherapy. |
|
Keywords
tonsillitis, periodontitis, pharyngitis, local immunity, oropharyngeal
secret, esberitox. |
|
Reference
- Gubler EV. [Mathematical methods of analysis and recognition of
pathological processes]. Leningrad: Medicine; 1978. 294 p. [In Russian].
- Ershov FI, Norovlyansky AN, Mezentseva MV. [Early cytokine reactions
in viral infections]. Cy-
tokines and inflammation. 2004; 3 (1): 3-6. [Article in Russian].
- Zabolotny DI, Melnikov OF, Timchenko SV, Zabolotnaya DG. [A study of
the oropharyngeal secretion in patients with chronic inflammatory and
allergic diseases of the upper respiratory tract: Guidelines]. Kiev;
2008. 34 p. [In Ukrainian].
- Kovalchuk LV, Gankovskaya LV, Meshkova RYa. [Clinical immunology and
allergology with the basics of general immunology]. Moscow:
GEOTAR-Media; 2011. 640 p. [In Russian].
- Kurchenko IF, Svidro SV, Savchenko VS. [The effect of Esberitox in
vitro on peripheral blood mononuclear cells of patients with herpes
virus infection]. Imunologiya ta alergologiya: nauka i praktika. 2016,
(1-4): 19-25. [Article in Ukrainian].
- Melnikov OF, Zabolotny DI, Kischuk VV, Bredun AY, Rylskaya OG.
[Immunology of chronic tonsillitis]. Kiev: Logos; 2017. 192 s. [In
Russian].
- Melnikov OF, Peleshenko ON, Zabolotnaya DD, Rylskaya OG. [Immunomodulation
with phytopreparations in the treatment of inflammatory diseases of the
upper respiratory tract]. Kiev; 2013. 108 p. [In Russian].
- Nasonov EL. Methodological aspects of determining circulating immune
complexes using polyethylene glycol. Terapevticheskiĭ arkhiv. 1987 (4).
38-45. [Article in Russian].
- Bredun O, Melnykov O. Immunological aspects in the selection of
tonsils pathology treatment methods. The 8th
International Symp. of Tonsills. Zurich; 2013. abstr. 02.
- Melnykov O, Zabolotny D. The concept of diagnosing secondary
immunodeficiency states based on determination of immunoglobulins in the
secretions. Intern. Jornal on Immunorehabilitation. 2004; 6(2): 235.
- Tjabringa GS, Vos JB, Olthuis D, Ninaber DK, Rabe KF, Schalkwijk J,
et al. Host defense effector molecules in mucosal secretions. FEMS
Immunol Med Microbiol. 2005 Aug 1;45(2):151-8. doi:
10.1016/j.femsim.2005.03.004.
- Yamanaka N. Moving towards a new era in the research of tonsils and
mucosal barriers. Adv Otorhinolaryngol.
2011;72:6-19. doi: 10.1159/000324586.
|
|
