No2-3(2) 2019
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DOI 10.37219/2528-8253-2019-2-41 |
Burlaka YuB, Gryn NV, Verevka SV
Assessment of the intensity of lipid peroxidation and catalase activity in
the blood-erythrocyte serum system in patients with laryngeal cancer |
Burlaka Julia B.
State Institution “Institute of otolaryngology named after Prof. O.S.
Kolomiychenko of the National Academy of Medical Sciences of Ukraine”; Kyiv,
Ukraine.
Laboratory of biochemistry
Researcher
PhD
E-mail: burlakaiuliia@yahoo.com
ORCID ID: http://orcid.org/0000-0003-0821-4268
Verevka Sergiy V.
State Institution “Institute of otolaryngology named after Prof. O.S.
Kolomiychenko of the National Academy of Medical Sciences of Ukraine”; Kyiv,
Ukraine
Laboratory of biochemistry, manager
Doctor of Biological Sciences, Professor
Email: verevka.biochem@gmail.com
ORCID ID: http://orcid.org/0000-0002-3578-7996
Grin Natalia V.
State Institution «O.S. Kolomiychenko Institute of Otolaryngology of
National Academy of Medical Sciences of Ukraine»
Department of Oncopathology of ENT Organs
Researcher
E-mail: natalia.zaitsevahryn@gmail.com
ORCID ID http://orcid.org/0000-0003-0970-3194 |
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Abstract
Aim: To evaluate the intensity of lipid peroxidation and the activity
of catalase in patients with laryngeal cancer.
Materials and Methods: Samples of blood serum and erythrocytes from
40 patients with laryngeal cancer of stages II and III and 20 healthy
volunteers were investigated.
Results: The level of TBA-positive products and diene conjugates in
blood serum samples of stage II and III patients with laryngeal cancer was
increased than that of control. In the same time catalase activity was
significantly reduced. In the erythrocytes of patients in both groups the
level of diene conjugates and catalase activity was higher than that of
control. The level of TBA-positive products increased only in patients with
III stage disease. Our results indicate the intensification of free-radical
oxidation against the background of the functional stress of the antioxidant
defense system in patients with laryngeal cancer, as well as the violation
of the structural and functional state of erythrocyte plasma membranes,
which is manifested in the activation of lipid peroxidation.
This indicates about the formation of a complex of disorders, which can play
a significant role in the development and deepening of the pathological
process. |
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Keywords
laryngeal cancer, erythrocytes, lipid peroxidation, catalase activity. |
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