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No6(2) 2019

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DOI 10.37219/2528-8253-2019-6-45
Kravets OV, Cherniienko VV
Survival of patients with resectable advanced oral cancer of different subsites
Kravets Oleg Vladimirovich
The National Cancer Institute
Department of head and neck tumors
Senior Researcher
Candidate of Medical Sciences
E-mail: kravetso.doc@ukr.net
ORCID ID: https://orcid.org/0000-0002-0226-6238

Cherniienko Viktor
The National Cancer Institute
Department of head and neck tumors
Surgeon-oncologist
E-mail: viktor.cherniienko@gmail.com
ORCID ID: https://orcid.org/0000-0002-5183-0667

Abstract

Objective: The aim of the study was to analyze the differences in survival of patients with resectable oral squamous cell carcinoma at stages III-IV of different oral cavity subsites and the impact of clinical and pathological factors on the prognosis of the disease.
Mаterials and methods: 295 patients with resectable oral squamous cell carcinoma at stages III-IV.
Results: Comparing the overall and free survival curves, no statistically significant difference between the different subsites was established (p=0.55 and p=0.77, respectively, according to the logrank test). Independent prognostic impact on overall and free survival of the disease stage was revealed during multivariate analysis (HR=3,44 (95% CI 2,33-5,06; p<0,001) and HR=3,57 (95% CI 2,42–5,28; p<0,001); presence of surgical complications (HR=2,50 (95% CI 1,76–3,56; p<0,001) and HR=2,46 (95% CI 1,73-3,50; p<0,001) respectively); positive resection margin HR=4,00 (95% CI 2,36-6,78; p<0,001) and HR=3,87 (95% CI 2,29-6,56; p<0,001) respectively); extracapsular extension (HR=2,57 (95% CI 1,75-3,79; p<0,001) and HR=2,43 (95% CI 1,65-3,58; p<0,001) respectively); multiple lymph node involvement (HR=2,41 (95% CI 1,63-3,55; p<0,001) and HR=2,53 (95% CI 1,71-3,73); high histopathological grade (HR=1,48 (95% CI 1,10-1,98; p=0,009) and HR=1,58 (95% CI 1,18-2,12; p=0,003) respectively).
Conclusion: The study found no statistically significant differences between overall survival and diseasefree survival in patients with advanced resectable oral squamous cell carcinoma of different oral subsites. The independent clinical prognostic factors of poor prognosis in patients with locally advanced resectable oral squamous cell carcinoma were stage IV and the presence of surgical complications. Independent pathological factors were: positive surgical margin, extracapsular nodal extension, multiple lymph node involvement and histopathological grade.

Keywords

oral squamous cell carcinoma; overall survival; disease-free survival; prognostic factors.


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