No3(4) 2021
Back to the issue
|
DOI 10.37219/2528-8253-2021-3-22 |
Melnikov O.F., Zabolotny D.I., Bredun O.Yu., Kishсhuk V.V.
Immunodiagnostics, immunotherapy and immunoprophylaxis in
otorhinolaryngological practice.
Report 3. Diagnostic approaches to the palatine tonsils functional state
assessment for selecting a treatment strategy for patients with chronic
tonsillitis (analytical summary) |
Melnikov Oleg F.
State Institution “Institute of otolaryngology named after Prof. O.S.
Kolomiychenko of the National Academy of Medical Sciences of Ukraine”; Kyiv,
Ukraine.
Head of the Laboratory of Pathophysiology and Immunology (with a group of
pathomorphology)
Doctor of Medical Sciences, Professor
E-mail: elenamelnykova@gmail.com
ORCID ID: 0000-0002-1261-8647
https://www.scopus.com/authid/detail.uri?authorId=7006385903
https://www.scopus.com/authid/detail.uri?authorId=7003452154
Zabolotny Dmitry I
State Institution “Institute of otolaryngology named after Prof. O.S.
Kolomiychenko of the National Academy of Medical Sciences of Ukraine”; Kyiv,
Ukraine. Director
Doctor of Medical Sciences, Professor, Academician of the National Academy
of Medical Sciences of Ukraine
E-mail: amtc@kndio.kiev.ua
https://www.scopus.com/authid/detail.uri?authorId=6701512931
ORCID ID: 0000-0001-9429-4414
Bredun Alexander Yu
Shupyk National Healthcare University of Ukraine (Kyiv, Ukraine)
Department of Pediatric Otorhinolaryngology, Audiology, Phoniatrics
Doctor of medical sciences, associate professor
E-mail: abredun@ukr.net
ORCID ID: http://orcid.org/0000-0002-5013-7318
Researcher ID: X-2623-2018
Kishchuk Vasyl V.
National Pirogov Memorial Medical University (Vinnytsya, Ukraine)
Department of Otolaryngology, Head of Department
Doctor of Medical Sciences, Professor
E-mail: kvv4488@ukr.net
Orchid ID: http://orcid.org/0000-0002-3390-2401 |
|
Abstract
Experimental work carried out over the past 20 years to study the activity
of various functional groups in tonsillar cells in patients with chronic
tonsillitis (CT) under local exposure to various immune response modifiers
showed that:
- tonsillar cells from CT patients in 69.5% of cases are capable of
increasing their immunofunctional activity under the influence of immune
modifiers in vitro reactions;
- the most active of the group of immunotropic immune response modifiers are
T-activin and Thymogen;
- it can be considered the optimal diagnostic technique to carry out a
"stress" test on the tonsil tissue using nonspecific (alternating magnetic
field of industrial (low) frequency and low-frequency ultrasound) and
specific — a microbial vaccine when applied to the tonsil tissue;
- a non-invasive method for recording changes in the tonsils after
stimulation may be fluctuations in the level of secretory immunoglobulin A
and α-interferon in saliva after the test;
- an increase in the level of secretory immunoglobulin A and α-interferon by
more than 1/3 of the initial level after the test is a clinically favorable
sign and a recommendation for medical treatment to the managing of patients
with CT. |
|
Keywords
chronic tonsillitis, saliva, tonsillar tissue, secretory immunoglobulin,
α-interferon. |
|
Reference
- Popa VA. [Chronic Tonsillitis]. Kishinew: Shtiintsa; 1984. [In
Russian]. 256 p.
- Zabolotny DI, Melnikov OF. [Theoretical aspects of the genesis and
therapy of chronic tonsillitis]. Kyiv: Zdorovya; 1999. [In Russian].
- Melnikov OF, Zabolotny DI, Kischuk VV, Bredun OY, Rylskaya OG.
[Immunology of chronic tonsillitis]. Kyiv: Logos; 2017. 192 p. [In
Russian].
- Popovich VI. [Tonsillitis]. Кyiv: Media group Ltd.; 2017. [In
Ukrainian].
- McIsaac W, Goel V, Tj T, Low D. Empirical validation of guideline
for the management of pharyngitis in children and adults. JAMA. 2004;
291(13):1587-95. doi: 10.1001/jama.291.13.1587.
- Windfuhr JP, Toepfner N, Steffen G, Waldfahrer F, Berner R. Clinical
practice guideline: tonsillitis I. Diagnostic and nonsurgical
management. Eur Arch Otorhinolaryngol. 2016;273(4):973-87. doi:
10.1007/s00405-015-3872-6.
- Melnikov OF. [Immunological aspects of the genesis of chronic
tonsillitis and regulation of the functional activity of the tonsils]
[dissertation]. Kyiv: Institute of Physiology of the Academy of Sciences
of the Ukrainian SSR; 1981. [In Russian].
- Zabolotny DI, Melnikov OF. [Clinical Immunology in Otolaryngology:
Achievements and Prospects]. Proceedings of the 10th
Otolaryngology Congress of Ukraine; 2010, p. 85. [In Russian].
- Melnikov OF. [The concept of diagnosis of immunodeficiency in
pathological processes]. Proceedings of the International
medico-pharmaceutical congress «Medicine and life»; 2004, p. 34-35. [In
Russian].
- Melnikov OF, Zayats TA. [Comparative evaluation of radioisotope and
spectrophotometric methods for registration of cytolysis]. Lab.
Diagnostics. 1999;(2):32-4. [In Russian].
- Kischuk VV. [Clinical and immunological approaches to the assessment
of the functional state of the tonsils for the diagnosis and treatment
of patients with chronic tonsillitis] [dissertation]. Kyiv, UA: SI
«INS-TE OF OTOLARYNGOLOGY OF NAMS»; 2001. 254 p. [In Russian].
- Melnikov OF, Zabolotny DD. [Diagnosis of immunodeficiency in mucosal
pathology based on the determination of immunoglobulins in secretions
(concept)]. Kyiv: SI «INS-TE OF OTOLARYNGOLOGY OF NAMS»; 2003. 28 p. [In
Russian].
- Lebedev KA, Ponyakina IV. [Immune deficiency (detection and
treatment)]. Nizhny Novgorod: NGMA; 2003. [In Russian].
- Bredun OY, Zabolotny DI, Melnikov OF, Kosakivskiy AL, inventors; SI
«INS-TE OF OTOLARYNGOLOGY OF NAMS», assignee. [A method of assessing the
function of the tonsils in patients with chronic tonsillitis]. Ukraine
patent UA112528. 2016 Dec 26. [In Ukrainian].
- Bredun OY. [Surgical and conservative treatment of children with
pathology of the tonsils (clinical and laboratory justification and
evaluation of the effectiveness of new approaches)] [dissertation].
Kyiv: SI «INS-TE OF OTOLARYNGOLOGY OF NAMS»; 2020. 375 p. [In
Ukrainian].
|
|
