No4(4) 2021
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DOI 10.37219/2528-8253-2021-4-62 |
Naumenko O, Abdelrazzaq A, Amirkhanova M
The role of bacteriotherapy in the restoration of the nasal mucosa in
patients with chronic rhinosinusitis |
Naumenko Alexander N.
Bogomolets National Medical University, Kiev, Ukraine
First vice-rector for scientific and pedagogical work and postgraduate
education
Doctor of Medical Sciences, Professor
E-mail: Naumenko@nmu.ua
https://orcid.org/0000-0002-5244-707X
Ahmad Abdelrazzaq Moh’dabdel razzaq
Bogomolets National Medical University, Kiev
Department of Otorhinolaryngology
Graduate student
E-mail: Daragoom4ek_87@hotmail.com
https://orcid.org/0000-0001-7160-7617
Amirkhanova Margaryta
Bogomolets National Medical University, Kiev
Department of Otorhinolaryngology
Department assistant
PhD
E-mail: Margaritaroma365@gmail.com
https://orcid.org/0000-0003-4106-5057 |
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Abstract
Topicality: Chronic rhinosinusitis is an polyetiological disease with
shch basic complaints as nasal obstruction, nasal discharge, headache or
facial pain and reduction of smell. The SNOT-22 questionnaire is widely used
to detail patient complaints in various fields. Chronic rhinosinusitis is
most often divided into chronic rhinosinusitis with polyps and without nasal
polyps. Given the large number of phenotypes and endotypes of the disease,
it is important to study further the mechanisms of pathogenesis and selec-
tion of individualized treatment.
Aim: to determine the role of topical application of Streptococcus
salivarius 24SMBc and Streptococcus orals 89a in the form
of nasal spray in improving the condition of the nasal mucosa in chronic
rhinosinusitis and reducing the recurrence rate.
Materials and methods: The study was conducted at the Department of
Otolaryngology of National Medical University on
the basis of KNP "Oleksandrivs’ka Clinical Hospital of Kyiv". It was
attended by 82 patients (38 women and 44 men) aged 18 to 60 years, who were
randomly divided into two groups. The 1st group (main, 43 patients) received
treatment: irrigation therapy with isotonic saline, topical corticosteroid
mometasone furoate in combination with a nasal spray, which contains
autochthonous saprophytes (AC) – Streptococcus salivarius 89SMBc and
Streptococcus orals 89a nasal mucus. The 2nd group (control, 39 patients)
received nasal saline irrigation therapy, topical corticosteroid mometasone
furoate in combination with topical antibiotic framicetin sulfate.
Assessment was performed according to the VAS scale, SNOT-22 questionnaire
(before treatment, on the 10th day of treatment and one month after the end
of therapy) and determining the frequency of relapses in patients of both
groups.
Results: According to the obtained results, the indicators of
patients of both groups before treatment and on the 10th day had
no statistically significant difference (p>0.05). However a month later
patients in the main group had better results (p<0.05) on the scale of VAS
and the SNOT-22 questionnaire. So, topical use of Streptococcus salivarius
24SMBc and Streptococcus orals 89a as a nasal spray is effective and can be
recommended for the treatment of patients with chronic rhinosinusitis in the
acute stage. |
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Keywords
chronic rhinosinusitis, bacteriotherapy, topical therapy, autochthonous
saprophytes, Streptococcus salivarius 24SMBc, Streptococcus orals 89a, YOUR,
SNOT-22. |
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