No4(4) 2021
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DOI 10.37219/2528-8253-2021-4-68 |
Bondarchuk AD, Melnykov OF, Timchenko MD, Didyk ND
Clinical and immunological studies of humoral factors of inflammation and
regeneration in patients with injuries of the frontal and basal area |
Bondarchuk Oleksandr D.
Mykola Pyrohov Vinnytsia Regional Hospital, Vinnytsia, Ukraine
Department of Otolaryngology
PhD
E-mail: eskulap20009@gmail.com
ORCID ID: https://orcid.org/0000-0002-7636-9694
Melnikov Oleg F.
State Institution “Institute of otolaryngology named after Prof. O.S.
Kolomiychenko of the National Academy of Medical Sciences of Ukraine”; Kyiv,
Ukraine.
Head of the Laboratory of Pathophysiology and Immunology (with a group of
pathomorphology)
Doctor of Medical Sciences, Professor
E-mail: elenamelnykova@gmail.com
ORCID ID: https://orcid.org/0000-0002-1261-8647
https://www.scopus.com/authid/detail.uri?authorId=7006385903
https://www.scopus.com/authid/detail.uri?authorId=7003452154
Timchenko Мarina D.
State Institution “Institute of otolaryngology named after Prof. O.S.
Kolomiychenko of the National Academy of Medical Sciences of Ukraine”; Kyiv,
Ukraine.
Senior Researcher
Laboratory of Pathophysiology and Immunology (with a group of
pathomorphology)
PhD
E-mail: svtim@i.ua
https://orcid.org/0000-0002-7889-1152
Didyk Natalia D.
Mykola Pyrohov Vinnitsa Regional Hospital, Vinnitsa, Ukraine
Eye microsurgery department
Doctor microsurgery eye
E-mail: didyknd@gmail.com
https://orcid.org/0000-0003-4313-1943 |
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Abstract
The authors conducted clinical and immunological research on the
identification of сytokine factors of inflammation and regeneration in
patients with frontal bone trauma (29) and practically healthy donors (11).
Factors of inflammation (interleukin-1β, γ-interferon), anti-inflammation
and regeneration (interleukin-34 and transforming growth factor – TGF-1β)
were determined in the blood serum by ELISA.
It was found that the content of the factor of regeneration decreases and
the levels of anti-inflammatory cytokines increase in the blood serum of the
patients with frontal traumas with frontal sinus damage. |
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Keywords
frontal-basal trauma, humoral immunity, interleukin-1β, interleukin 10,
γ-interferon, interleukin-4, transforming growth factor TGF-1β. |
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