SCIENTIFIC-PRACTICAL JOURNAL

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No4(4) 2021

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DOI 10.37219/2528-8253-2021-4-79

Ivasivka KP, Paltov EV, Masna ZZ, Kryvko YY, Cherkes MB
Dynamics of changes in the structural components of the mucosa and cartilage of the larynx of rats at the end of 28th and 35th days of experimental opioid exposure   
Ivasivka Khrystyna P.
Danylo Halytskyi Lviv National Medical University
Department of Normal Anatomy
Postgraduate student
https://orcid.org/0000-0003-4372-225х

Paltov Evgeniy V.
Danylo Halytskyi Lviv National Medical University
Department of Normal Anatomy
Candidate of Medical Sciences, Associate Professor
E-mail: evgenpaltov@gmail.com
https://orcid.org/0000-0002-2622-4753

Masna Zoryana Z
Danylo Halytskyi Lviv National Medical University
Head of the Department of Operative Surgery with Topographic Anatomy
Doctor of Medical Sciences, Professor
E-mail: masna.zz@gmail.com
https://orcid.org/0000-0003-2057-7061

Kryvko Yuri Ya
Lviv Medical Academy named after Andrey Krupinsky
Rector
Doctor of Medical Sciences, Professor
E-mail: ykryvko@ukr.net
https://orcid.org/0000-0002-2740-7703

Cherkes Maryana B
Danylo Halytskyi Lviv National Medical University
Department of Operative Surgery with Topographic Anatomy
E-mail: maryana.cherkes@gmail.com
https://orcid.org/0000-0002-6553-974x

Abstract

In our work we aimed to conduct a fundamental study of the process of morphological disorganization of the structural components of the mucous membrane and cartilage of the larynx at the end of the 28 and 35 days of experimental opioid effects at the microstructural level.
This information in the future will allow to form a pathomorphological base, which will be used to compare the components of the mucous membrane and cartilage of the larynx in the norm with the dynamics of their changes as a result of experimental opioid effects at different times.

Keywords

pathomorphology, mucosa, laryngeal cartilage, opioid effect, rat.


Reference

  1. Radomskyy VT, Serehyna NM, Dyskovskyy IS. ВТ. [Features of the microstructure of rat skin under conditions of opioid exposure]. Eksperymentalʹna i klinichna medytsyna. 2014;(3):61-4. [Article in Ukrainian].
  2. Tabachnikov SI, Lebedev DS, Trofimchuk GE. [Epidemiological situation in the use of psychoactive substances in Ukraine]. Arkhiv psykhiatrii. 2009;15(1) (56):81-8 [Article in Ukrainian].
  3. Clausen T, Anchersen K, Waal H. Mortality prior to, during and after opioid maintenance treatment (OMT): a national prospective cross-registry study. Drug Alcohol Depend. 2010;94(1):151-7.
  4. Akshat S, Ramachandran R, Rewari V. Morphine versus Nalbuphine for open gynaecological surgery: a randomized controlled double blinded trial. Pain Res. Treat. 2014. Available from: http://www.hindawi. com/journals/prt/2014/727952/.
  5. Narver HL. Nalbuphine, a non-controlled opioid analgesic, and its potential use in research mice. Lab Anim (NY). 2015;44(3):106-10.
  6. Copeland L, Robertson J, McKenzie J, Kimber J, Macleod J [et al.] Premature mortality in Scottish injecting drug users: a life-history approach. Scott Med J. 2012;57(1):38-42. doi: 10.1258/smj.2011. 011289.
  7. Deering D, Sellman JD, Adamson S. Opioid substitution treatment in New Zealand: a 40 year perspective. The New Zealand medical journal. 2014; 127(1397):57-66.
  8. Schnabel A, Reichl SU, Zahn PK. Nalbuphine for postoperative pain treatment in children. Cochrane database of systematic reviews. 2014;7(7): CD009583. DOI:10.1002/14651858.CD009583. pub2.
  9.  Tabachnikov SI, Viyevsʹkyy AM, Zhdanova MP. [Clinical features and leading factors of substance use in children and adolescents for the development
    of a comprehensive multi-level system of its medical and social correction and prevention]. Ukrayinsʹkyy zhurnal klinichnoyi ta laboratornoyi medytsyny. 2012;7(1):4-10. [Article in Ukrainian].
  10. Litvintsev BS. [Structural and functional changes in the nervous system in chronic opioid poisoning] [dissertation]. Moscow; 2003. 23 p. [In Russian].
  11. Onysʹko RM, Palʹtov YV, Fik VB, Vilʹkhova IV, Kryvko YYa, Yakymiv NYa, Fitʹkalo OS, inventor; Danylo Halytskyi Lviv National Medical University, assignee. [Method for modeling physical opioid dependence in rats]. Patent of Ukraine 76564 U. 2013 Jan 10.
  12. Romeys B. [Microscopic technique]. Moscow: Foreign Languages Publishing House; 1953. 719 p. [in Russian].
  13. Horalʹsʹkyy LP., Khomych VT., Kononsʹkyy OI. [Basics of histological technique and morphofunctional research methods in health and disease].
    Study guide. 3rd edition. Zhytomyr: Polissya; 2015. 286 p. [in Ukrainian].
  14. Onysʹko RM., Onysʹko IO. [Microstructural organization of the tongue tissue on the 28th day after opioid withdrawal]. Novyny stomatolohiyi. 2013; 76(3):101-6. [in Ukrainian].
  15. Yakymiv NYa. [Ultrastructural characteristics of the structures of the iris-corneal angle of the eyeball of rats on the 7th, 14th, 21st and 28th days of opioid influence]. Ukrayinsʹkyy morfolohichny alʹmanakh. 2014;(2):28-31. [Article in Ukrainian].
  16. Yakymiv NYa. [Morphological characteristics of the structures of the iris-corneal angle of rats on different lines of action and on different lines after canceling experimental opioid influence]. Ophthalmology. Eastern Europe. 2014;(2):89-97. [Article in Russian].
  17. Palʹtov EV, Chelpanova IV, Fik VB, Vilʹkhova IV, Kyryk KhA, Kryvko YYa. [Pathological changes in the layers of the retina after 6 weeks of opioid exposure in the experiment]. World of Medicine and Biology. 2017;60(2):146-50. [Article in Ukrainian].
  18. Palʹtov EV, Kryvko Y.Ya. [Pathological changes in the layers of the retina after 8 weeks of opioid exposure in the experiment]. Visnyk problem biolohiï i medytsyny. 2017;2(140):118-22. [Article in Ukrainian].
 

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