No5(4) 2021
Back to the issue
|
DOI 10.37219/2528-8253-2021-5-27 |
Lukach EV, Serezhko YO, Klochkov EI, Strezhak VV, Tsymbalyuk
EM, Dikhtyaruk VY
Some aspects of conservative treatment of patients with laryngeal cancer |
Lukach Erwin V.
State Institution “O.S. Kolomiychenko Institute of Otolaryngology of
National Academy of Medical Science of Ukraine”; Kyiv, Ukraine
Head of Department of Oncological Diseases of ENT Organs
Doctor of Medical Sciences, Professor
E-mail: erwin@lukach.org
ORCID ID: https://orcid.org/0000-0003-3262-4996
https://www.scopus.com/authid/detail.uri?authorId=6602607907
Serezhko Yurij O.
State Institution “O.S. Kolomiychenko Institute of Otolaryngology of
National Academy of Medical Science of Ukraine”; Kyiv, Ukraine
ENT oncology department
PhD, Researcher
email: yualse2016@ukr.net
Klochkov Evgenij I.
State Institution “O.S. Kolomiychenko Institute of Otolaryngology of
National Academy of Medical Science of Ukraine”; Kyiv, Ukraine
Laboratory of Pathophysiology and Immunology (with a group of
pathomorphology)
Researcher
email: ekbox@ukr.net
Strezhak Valerii V.
State Institution “O.S. Kolomiychenko Institute of Otolaryngology of
National Academy of Medical Science of Ukraine”; Kyiv, Ukraine
ENT oncology department
Researcher
email: strezhakv@ukr.net
Tcimbalyuk Evgeniya M.
State Institution “O.S. Kolomiychenko Institute of Otolaryngology of
National Academy of Medical Science of Ukraine”; Kyiv, Ukraine
ENT oncology department
Researcher
email: ecimbaliuk@gmail.com
Dihtyaruk Viktor Ya.
State Institution “O.S. Kolomiychenko Institute of Otolaryngology of
National Academy of Medical Science of Ukraine”; Kyiv, Ukraine
ENT oncology department
PhD, Researcher
email: dikhtyaruk@ua.fm |
|
Abstract
Topicality: According to the National Cancer Registry of Ukraine, the
incidence of laryngeal cancer is 4.1%. The treatment of patients with
laryngeal cancer depends on the stage of the tumor. The conservative therapy
includes both radiation therapy and chemotherapy.
Material and methods: The conservative treatment of 93 patients with
laryngeal cancer was performed. All patients are divided into two groups
according to the localization of cancer: glottis (n=57) and supraglottis
(n=36). The course of radiation therapy was conducted in oncology centers.
The course of chemotherapy was induction or combined with radiation therapy.
The outcome of therapy was evaluated one month after its completion. Tumor
response after therapy was assessed by RECIST 1.1. Statistical processing of
the obtained results was performed in accordance with the recommendations of
Glantz.
Results: It was found that metastases to the lymph nodes of the neck
were significantly more common in cancer of the supraglottic (χ2=16.074;
φ=0.00012; р<0.05). The greater number of recurrences of the tumor of the
glottis after conservative therapy (χ2=6.718; φ=0.01345; р<0.05). Three-year
recurrence-free survival and overall survival of patients after conservative
treatment of laryngeal cancer patients were the same in both groups.
Conclusion: The treatment of 93 patients with laryngeal cancer gave
an objective tumor response in 96% of patients. The conservative treatment
of patients with laryngeal cancer revealed a lower number of tumor
recurrences in the supraglottis cancer (20 of 36 patients) compared with the
glottis (37 of 57) (χ2= 6.718; φ = 0.01345; p <0.05). |
|
Keywords
cancer, larynx, conservative treatment. |
|
Reference
- [Cancer in Ukraine, 2019-2020. Incidence, mortality, rates for
activity of oncological service]. Bulletin of national cancer Registry
of Ukraine. Kyiv. 2021;22:136 p. [In Ukrainian].
- NCCN Guidelines. Head and Neck Cancer. Version 3.2021. Springer;
2021. 245 p.
- Suбrez-Quintanilla J, Cabrera AF, Sharma S. Anatomy, Head and Neck,
Larynx. 2021. https:// www.ncbi.nlm.nih.gov/books/NBK538202/.
- Serezhko YuA. [Drawing up a diagnosis in ENT oncology. Help manual].
Kyiv: Foliant; 2019. 140 p. [In Ukrainian].
- Glantz S. [Biomedical statistics]. Moscow: Practice; 1998. 459 p.
[In Russian].
|
|
