No5(5) 2022
Back to the issue
|
DOI 10.37219/2528-8253-2022-5-86 |
Bezega M, Bezshapochny S, Loburets V, Loburets A, Dzhirov O
Rhinocerebral mucoromycosis. Clinical case |
Bezega Mychailo
Poltava State Medical University
Department of Otorhinolaryngology with Ophthalmology
Candidate of Medical Sciences
Email: bezega_lor@ukr.net, lorbezega@gmail.com
ORCID ID: https://orcid.org/0000-0002-1250-1190
Bezshapochny Sergey B.
Poltava State Medical University
Professor of Department of Otorhinolaryngology with Ophthalmology
Doctor of Medical Sciences, Professor.
Email: bezshapochny@ukr.net
https://orcid.org/0000-0002-8726-2024
Scopus Author ID: 6603471609
Loburets Valery V.
Ukrainian Medical Stomatological Academy
Department of Otolaryngology with Ophthalmology
PhD, Docent
Email: umsalor@gmail.com
http://orcid.org/0000-0001-8538-9649
Loburets Andrey V.
Ukrainian Medical Stomatological Academy
Department of Otolaryngology with Ophthalmology
PhD, Assistant of the department
E-mail: anjeyloburets@gmail.com
http://orcid.org/0000-0003-4164-0816
Dzhirov Oleksiy R
Poltava State Medical University
Department of Otorhinolaryngology with Ophthalmology
Assistant of the Department
Email: mrskivi58@gmail.com
https://orcid.org/0000-0003-0895-5461 |
|
Abstract
In recent years, there has been an increase in the number in Ukraine and the
world clinical cases of various forms of mucoromycosis. It can be associated
with severe immunosuppression caused by transmitted SARS-CoV-2, an increase
in the number of patients with diabetes, which creates favourable conditions
for development of fungal microflora.
Rhinocerebral mucormycosis is usually severe and often fatal if not
diagnosed early and actively treated.
Necrotic lesions appear on the nasal mucosa or sometimes on the palate.
Vascular invasion of hyphae leads to thrombosis and progressive tissue
necrosis, which may involve the nasal septum, palate and bones, surrounding
the orbit or sinuses.
Verification of the diagnosis is difficult due to the inexperience of
doctors in working with this disease, the disease has a tendency to progress
rapidly.
The article describes the case of treatment of a patient with rhinocerebral
mucoromycosis, which had a severe clinical course. |
|
Keywords
mucoromycosis, fungal rhinosinusitis, amphotericin B, antifungal therapy,
diagnosis of mucorosis. |
|
Reference
- Vaughan C, Bartolo A, Vallabh N, Leong SC. A meta-analysis of
survival factors in rhino-orbital-cerebral mucormycosis – has anything
changed in the past 20 years? Clin Otolaryngol. 2018;43(6): 1454-64. doi:
10.1111/coa.13175.
- Prakash H, Chakrabarti A. Global Epidemiology of Mucormycosis. J
Fungi (Basel). 2019;5(1):26. doi:10.3390/jof5010026.
- Herbrecht R, Letscher-Bru V, Bowden RA, Kusne S, Anaissie EJ,
Graybill JR, Noskin GA, Oppenheim, Andrиs E, Pietrelli LA. Treatment of
21 cases of invasive mucormycosis with amphotericin B colloidal
dispersion. Eur J Clin Microbiol Infect Dis. 2001;20(7):460-6. doi:
10.1007/s100960100528.
- Vehreschild JJ, Birtel A, Vehreschild MJ, Liss B, Farowski F,
Kochanek M, Sieniawski M, Steinbach A, Wahlers K, Fдtkenheuer G, Cornely
OA. Mucormycosis treated with posaconazole: review of 96 case reports.
Crit Rev Microbiol. 2013; 39(3):310-24. doi:
10.3109/1040841X.2012.711741.
- Bhansali A, Bhadada S, Sharma A, Suresh V, Gupta A, Singh P,
Chakarbarti A, Dash RJ. Presentation and outcome of
rhino-orbitalcerebral mucormycosis in patients with diabetes. Postgrad
Med J. 2004; 80(949):670-4. doi:10.1136/pgmj.2003.016030.
- Corzo-Leуn DE, Chora-Hernбndez LD, Rodrнguez-Zulueta AP, Walsh TJ.
Diabetes mellitus as the major risk factor for mucormycosis in Mexico:
Epidemiology, diagnosis, and outcomes of report-
ed cases. Med Mycol. 2018;56(1):29-43. doi: 10. 1093/mmy/ myx017.
- Sridhara SR, Paragache G, Panda NK, Chakrabarti A. Mucormycosis in
immunocompetent individuals: an increasing trend. J Otolaryngol. 2005;
34(6):402-6. doi: 10.2310/7070.2005.34607.
- Goh LC, Shakri ED, Ong HY, Mustakim S, Shaariyah MM, Ng WSJ,
Zulkiflee AB. A sevenyear retrospective analysis of the
clinicopathological and mycological manifestations of fungal
rhinosinusitis in a single-centre tropical climate hospital. J Laryngol
Otol. 2017;131(9):813-6. doi: 10.1017/S0022215117001505.
- Hoenigl M, Gangneux JP, Segal E, Alanio A, Chakrabarti A, Chen SC,
Govender N, Hagen F, Klimko N, Meis JF, Pasqualotto AC, Seidel D, Walsh
TJ, Lagrou K, Lass-Flцrl C, Cornely OA, European Confederation of
Medical Mycology (ECMM). Global guidelines and initiatives from the
European Confederation of Medical Mycology to improve patient care and
research world-
wide: New leadership is about working together. Mycoses.
2018;61(11):885-94. doi: 10.1111/myc.12836.
- Vallverdъ Vidal M, Iglesias Moles S, Palomar Martнnez M.
Rhino-orbital-cerebral mucormycosis in a crit ically ill pat ient. Med
Intensiva. 2017;41(8): 509-10. doi: 10.1016/j.medin.2016.03.001.
[Article in English, Spanish].
- Cornely OA, Alastruey-Izquierdo A, Arenz D, Chen S, Dannaoui E,
Hochhegger B, et al. Global guideline for the diagnosis and management
of mucormycosis: an initiative of the European Confederation of Medical
Mycology in cooperation with the Mycoses Study Group Education and
Research Consortium. Lancet Infect Dis. 2019;19(12):e405-e421.
doi:10.1016/S1473-3099(19) 30312-3.
- Ramadorai A, Ravi P, Narayanan V. Rhinocerebral Mucormycosis: A
Prospective Analysis of an Effective Treatment Protocol. Ann Maxillofac
Surg. 2019;9(1):192-6. doi: 10.4103/ams.ams_ 231_18.
- Zaman K, Rudramurthy SM, Das A, Panda N, Honnavar P, Kaur H,
Chakrabarti A. Molecular diagnosis of rhino-orbito-cerebral mucormycosis
from fresh tissue samples. J Med Microbiol. 2017;66(8): 1124-9. doi:
10.1099/jmm.0.000560.
- Maini A, Tomar G, Khanna D, Kini Y, Mehta H, Bhagyasree V.
Sino-orbital mucormycosis in a COVID-19 patient: A case report. Int J
Surg Case Rep. 2021 May; 82: 105957. Published online 2021 May 4. doi:
10.1016/j.ijscr.2021.105957.
- Davoudi S, Anderlini P, Fuller GN, Kontoyiannis DP. A long-term
survivor of disseminated Aspergillus and mucorales infection: an
instructive case. Mycopathologia. 2014;178(5-6):465-70. doi:
10.1007/s11046-014-9785-x.
|
|
