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No6(5) 2022

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DOI 10.37219/2528-8253-2022-6-02
Zabolotnyi DI, Shydlovska TA, Dieieva YuV, Petruk LG, Bezeha MI, Verevka SV
Systemic endothelium damage and its functional consequences under the action of injuries and infectious agents 
Zabolotnyi Dmitry I
State Institution “O.S. Kolomiychenko Institute of Otolaryngology of National Academy of Medical Science of Ukraine”; Kyiv, Ukraine. Director
Doctor of Medical Sciences, Professor, Academician of the National Academy of Medical Sciences of Ukraine
E-mail: amtc@kndio.kiev.ua
https://www.scopus.com/authid/detail.uri?authorId=6701512931
ORCID ID: https://orcid.org/0000-0001-9429-4414

Shidlovskaya Tetiana A.
State Institution “O.S. Kolomiychenko Institute of Otolaryngology of National Academy of Medical Science of Ukraine”; Kyiv, Ukraine.
Head of the laboratory of voice and hearing
Doctor of Medical Sciences, Professor
E-mail: lorprof3@ukr.net
Orchid ID: https://orcid.org/0000-0002-7894-359X

Dieieva Julia V.
MD, PhD, professor
Head of the department of Otorhinolaryngology
Bogomolets National Medical University, Kiev
E-mail: deyeva@bigmir.net
ORCID ID: 0000-0003-0552-1254
https://www.scopus.com/authid/detail.uri?authorId=55359076200

Petruk Lyubov G.
Odessa National Medical University
Department of military medicine and disaster medicine
Associate professor of the department
Doctor of Medical Sciences
E-mail: lyubovpetruk0@gmail.com
Orchid ID: http://orcid.org/0000-0002-1261-7054

Bezega Mychailo
Poltava State Medical University
Department of Otorhinolaryngology with Ophthalmology
Candidate of Medical Sciences
Email: bezega_lor@ukr.net, lorbezega@gmail.com
ORCID ID: https://orcid.org/0000-0002-1250-1190

Verevka Sergiy V.
State Institution “O.S. Kolomiychenko Institute of Otolaryngology of National Academy of Medical Science of Ukraine”; Kyiv, Ukraine.
Laboratory of biochemistry, manager.
Doctor of Biological Sciences, Professor.
Email: verevka.biochem@gmail.com
ORCID ID: http://orcid.org/0000-0002-3578-7996
Scopus Author ID: 6701564791

Abstract

Topicality: Blockage of hemorrhage due to vascular damage is the leading role of the clotting cascade of the hemostasis system. Recently, two types of such damage have become highly relevant. The first of them is caused by viral damage to the endothelium, which leads to uncontrolled cascade activation of the descending system. The second type is caused by aquabarotrauma and associated hydrodynamic shock. Both types of damage lead to the development of thrombotic-fibrous complications of the circulatory system due to the formation of long fibrin deposits. Such deposits are resistant to the action of the fibrinolytic system due to their irregular and chaotic structure. This, in turn, leads to severe functional complications.
Aim: Systematize data on molecular and cellular features of systemic damage to the endothelium. To compare the clinical material of persons who suffered from or died of COVID-19. To compare the functional disorders of the hearing organs in persons who have experienced akubarotrauma or who have become ill with COVID-19.
Results and discussion: The clinical material of persons who suffered from COVID-19 or died as a result of it is presented. The functional disorders of the hearing organs in persons who have experienced acubarotrauma or who have become ill with COVID-19 are considered. The reasons for the resistance of thrombotic-fibrous deposits in vessels with systemically damaged endothelium are discussed. Possible methodical approaches to overcoming the considered functional complications are discussed.

Keywords

sensorineural deafness, hearing disorders, Covid-19, acubarotrauma, thrombosis, hemostatic system


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