No2(1) 2018
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DOI 10.37219/2528-8253-2018-2-13 |
Melnikov ОF, Zabolotnaya DD, Bredun АY, Bil BN, Rylskaya ОG,
Isnyuk АS,
Timchenko МD, Vakhnina АP, Faraon ІV
Humoral factors of innate immunity in the saliva of patients with infectious
inflammatory respiratory diseases |
Melnikov Oleg F.
State Institution “Institute of otolaryngology named after Prof. O.S.
Kolomiychenko of the National Academy of Medical Sciences of Ukraine”; Kyiv,
Ukraine. Head of the Laboratory of Pathophysiology and Immunology (with a
group of pathomorphology), Doctor of Medical Sciences, Professor
E-mail: elenamelnykova@gmail.com
Zabolotnaya Diana D
State Institution “Institute of otolaryngology named after Prof. O.S.
Kolomiychenko of the National Academy of Medical Sciences of Ukraine”; Kyiv,
Ukraine.
Clinical Allergology Department, Leading Researcher, MD
E-mail: dianazab@ukr.net
Bredun Alexander Yu
National Medical Academy of Post-Graduate Education Named After P.L. Shupik
Department of Pediatric Otorhinolaryngology, Audiology, Phoniatrics
Associate Professor, PhD.
E-mail: abredun@ukr.net
Bil Bogdan N.
Chief otolaryngologist in Kiev, head of the State Research Center for
Endoscopic Rhinolaryn-gology and the City Phoniatric Center, head of the
department of otolaryngology of the Kiev City Clinical Hospital No. 9,
candidate of medical sciences, associate professor of the Depart-ment of
Otolaryngology of the Shupik National Medical Academy of Postgraduate
Education.
E-mail: bohdanbill@gmail.com
Rylska Oksana G.
State Institution “Institute of otolaryngology named after Prof. O.S.
Kolomiychenko of the National Academy of Medical Sciences of Ukraine”; Kyiv,
Ukraine. Senior Researcher at the Department of Inflammatory Diseases of ENT
Organs, PhD.
Email: oxanar@ua.fm
Timchenko Мarina D.
State Institution “Institute of otolaryngology named after Prof. O.S.
Kolomiychenko of the National Academy of Medical Sciences of Ukraine”; Kyiv,
Ukraine. Senior Researcher, Labor-atory of Pathophysiology and Immunology
(with a group of pathomorphology), candidate of biological sciences.
E-mail: svtim@i.ua
Faraon Inna V
State Institution “Institute of otolaryngology named after Prof. O.S.
Kolomiychenko of the National Academy of Medical Sciences of Ukraine”; Kyiv,
Ukraine, Junior Researcher, Labor-atory of Pathophysiology and Immunology
(with a group of pathomorphology).
E-mail: amtc@kndio.kiev.ua |
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Abstract
Introduction: In recently ears factors of innate immunity both
cellular and humoral have been paid considerable attention as they are a
protective barrier of a fast response and that is why they are largely
concentrated at the intersection of the digestive tract and airways. The
data concerning the activity level of factors of innate immunity in the
upper airways affected by nonspecific inflammatory processes is insufficient
and sparse and therefore the purpose of this research was to study the
content of humoral factors of innate immunity in the oropharyngeal secretion
(ORS) of patients with chronic infectious inflammatory diseases of the upper
airways in remission.
Materials and Methods: There was an examination of 16 patients with
chronic rhinosinusitis (CRS) of bacterial genesis (15-40 years old), 12
patients with rhinopharyngitis of post-viral genesis (8-16 years old), 12
people with scleroma from 30 tо 52 years of age (atrophic form), 10 patients
with chronic tonsillitis in remission (from 10 to 33 years of age) and 11
patients of a control group (practically healthy donors from 12 tо 40 years
of age).
The content of MIP-1b, defensin-1β, lactoferrin, lysozyme, α-interferon was
studied in the nonstimulated OPS. Statistics were carried out using
Mann-Whitney U-test.
Results: The greatest number of deviations in the decrease in the
content of the examined nonspecific protective factors was found in cases of
scleroma, chronic tonsillitis and chronic rhinosinusitis (p<0,05). The lack
of protective humoral factors of innate immunity can be evidence of local
immunodeficiency even in remission, which is a pathophysiological component
of the maintenance of chronic inflammation.
Conclusion: The decrease int he quantitative composition of factors
of innate immunity in the oropharyngeal secretion of patients with chronic
infectious inflammatory diseases of the airways is an objective ground not
only for a replacement therapy, but also for the use of immune response
modifiers from photo-immune modulators to “genuine immune modulators”
controlling the state of the factors of both innate immunity and
immunoglobulins, primarily of secretory type, the level and functionality of
various groups of immunocompetent and accessory cells. |
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Keywords
innate immunity, humoral factors, inflammatory diseases of the upper
respiratory tract. |
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