No2(1) 2018
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DOI 10.37219/2528-8253-2018-2-50 |
Kazachonok TM, Petrova LG
The effectiveness of glucocorticoid hormones in the treatment of
sensorineural disorders |
Kazachonok Tatyana M.
Belarusian Medical Academy of Postgraduate Education, Minsk, Belarus
Department of Otorhinolaryngology, Assistant of the Department
E-mail: dr.ktm@mail.ru
Petrova Lyudmila G.
Belarusian Medical Academy of Postgraduate Education
Head of the Department of otorhinolaryngology
Doctor of Medical Sciences, professor
E-mail: info@belmapo.by |
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Abstract
Topicality: Effective treatment of acute sensorineural hearing loss
is still relevant due to the fact that the number of diseases accompanied
with impaired sound perceptions great, and the treatment outcome is often
far from the desire done. Many researchers have noted the positive effect of
systemic glucocorticoids in the treatment of acute hearing loss. Adverse
effect sin case of long-term systemic use of hormones, such as insomnia,
gastric ulcer, impaired glucose tolerance, arterial hypertension, etc.,
limitations or contraindications to their administration in patients with
severe concomitant pathology, the existence of a hemato-perilymphatic
barrier, which prevents penetration of glucocorticoids in to the inner
environment of the ear, promote the wider use of intratympanic
administration of hormones.
The purpose of this study was to evaluate treatment effectiveness
following intratympanic administration of glucocorticoid hormones in
patients with acute sensorineural hearing loss and exudative otitis media.
Materials and methods: Analysis was performed to compare treatment
outcomes of 92 patients (the main group) with acute sensorineural hearing
loss who were administered hormones intratympanically, with the treatment
outcomes of 315 patients (the control group) receiving conventional therapy.
Treatment outcomes of 23 patients with acute otitis media with effusion
accompanied with combined hearing loss with a pronounced sensorineural
component were analyzed.
Results and discussion: As a result of the treatment, a statistically
significant improvement in hearing was obtained in the main group compared
to the control group. Of the 23 patients with otitis media with effusion who
received the treatment, hearing has restored to the norm in 19 people, and
the rest showed an improvement. Thus, intratympanic administration of
glucocorticoids increases treatment effectiveness in patients with acute
sensorineural hearing loss and helps to restore disturbed sound perception
in the treatment of patients with otitis media with effusion. |
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Keywords
glucocorticoids (GCs), acute sensorineural hearing loss (ASHL), otitis
media with effusion, tonal threshold audiometry. |
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Reference
- Atanesyan A. [Modern trends in the treatment of acute sensorineural
hearing loss]. Consilium medicum, no 11, pp. 57-63. [Article in
Russian].
- Vishniakov VV, Sorokina MV. [The transtympanic administration of
steroids for the treatment of acute sensorineural hearing impairment].
Vestn Otorinolaringol. 2014;(4):55-8. [Article in Russian].
- Guseynov NM. Impaired hearing and microcirculation in acute
neurosensory hearing loss. Vestn Otorinolaringol. 2006; (5): 151-2.
[Article in Russian].
- Kosyakov S, Atanesyan A. [Intratimpanic introduction of
glucocorticosteroids in the treatment of acute sensorineural hearing
loss]. Vestn Otorinolaringol. 2006; (5): 158-9. [Article in Russian]
- Kunel'skaya N, Polyakova T. [Sensorineural hearing loss. Principies
of treatment]. 2006; (5): 161-3. Vestn Otorinolaringol. 2006; (5):
161-3. [Article in Russian]
- Men'shhikova E. [Oxidative stress. Pro-oxidants and antioxidants].
Moscow: Slovo; 2006. 553 p. [In Russian].
- Petrovich Yu. [Free-radical oxidation and its role in the
pathogenesis of inflammation, ischemia and stress]. Pat Fiziol Eksp Ter.
2001; (5): 85-92. [Article in Russian].
- Titov V. [Antioxidant activity of blood serum – test of impared
biological function of endoecology, exotrophy and inflammatory
reactions]. Klin. Lab. Diagn. 2010; (7): 3-14. [Article in Russian].
- Shushkova I., Ostrovskij O., Zajcev V. (2012) [Population-based
study of total antioxidant activity of human blood serum and urine].
Klin. Lab. Diagn. 2012; (5): 2-16. [Article in Russian].
- Banerjee A, Parnes LS. Intratympanic corticosteroids for sudden idiopathic sensorineural hearing
loss. Otol Neurotol.
2005 Sep;26(5):878-81.
- Conlin AE, Parnes LS. Treatment of sudden sensorineural hearing loss. I. A systematic review. Arch
Otolaryngol Head Neck Surg. 2007;133(6):573-81.
doi: 10.1001/archotol.133.6.573.
- Goycoolea MV. Clinical aspects of round window
membrane permeability under normal and pathological
conditions. Acta Otolaryngol. 2001 Jun;121(4):437-47.
- Qiu JX, Duan ML. A surgical approach to middle
ear can preserve rat cochlear function. Chin Med J
(Engl). 2004
May;117(5):767-9.
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