No5-6(3) 2020
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DOI 10.37219/2528-8253-2020-6-42 |
Dityatkovska E.M., Biletska S.V.
Dynamics of class E and G immunoglobulins under the influence of combined
allergen-specific immunotherapy in patients with allergic rhinitis with
combined sensitization to pollen and household allergens |
E.М. Dityatkovska
Dnipropetrovsk Medical Academy of Ministry of Health of Ukraine,
Department of Vocational Diseasesand Clinical Immunology,
Department of Family Medicine
S.V. Biletska
Stefan Żeromski Specialized Hospital in Krakow, Poland
E-mail: biletskasv@gmail.com |
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Abstract
The aim of this study is to assess the dynamics of
immunoglobulin E and G under the influence of combined allergen-specific
immunotherapy (ASIT) in patients with allergic rhinitis with combined
sensitization to pollen and household allergens.
Materials and methods: The study involved 49 patients, residents of
Dnipro city, of working age (35,5±1,5 years), of whom 24 (49,0%) - women and
25 (51,0%) - men. All patients were diagnosed with allergic rhinitis with
average disease duration of 9,2 ±1,1 year, who underwent allergy examination
- skin tests - prick test with pollen and household allergens and/or methods
of allergy component diagnosis ALEX. The number of pollen allergens in one
patient was 4,6±0,4 on average. All patients received one course of
pre-season ASIT allergen according to the express scheme. Patients in the
main group (31 patients) received a combined ASIT with solutions of pollen
and household allergens. 18 patients in the comparison group received ASIT
only with pollen allergens. Clinical groups were homogeneous in age, sex,
duration of the disease, as well as the average number of pollen allergens.
Results: The obtained results and their analysis show that the use of
allergen-specific combination immunotherapy in patients with allergic
rhinitis with combined sensitization to pollen allergens causes a more
significant effect on the activation of the immune response, which was
revealed by reduced relative to baseline lgE production by 41,9% (p<0,001)
and an increase in lgG by 7,5% (p<0,05). The production of total serum in
patients with allergic rhinitis before treatment and under the influence of
ASIT was the opposite to the dynamics of lgG production.
The positive results of immunological studies convincingly prove the
benefits and effectiveness of allergen-specific combination immunotherapy in
the treatment of patients with allergic rhinitis with combined sensitization
to pollen and household allergens. |
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Keywords
allergic rhinitis, allergen-specific immunotherapy, IgE, IgG. |
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